Japanese geneticist Hiromitsu Nakauchi will be heading up a team of scientists that will be growing human-animal hybrids, a.k.a. chimeras, in a laboratory as science-fiction truly becomes science fact.
Scientists will be conducting the experiment at the University of Tokyo where they will be splicing human genes with those of animals as covered in Greek mythology.
The term “chimera” has come to describe any mythical or fictional animal with parts taken from various animals, or to describe anything composed of very disparate parts, or perceived as wildly imaginative, implausible, or dazzling.
From Merriam-Webster Dictonary:
1a: capitalized : a fire-breathing she-monster in Greek mythology having a lion’s head, a goat’s body, and a serpent’s tail
b : an imaginary monster compounded of incongruous parts
2 : an illusion or fabrication of the mind especially : an unrealizable dream
a fancy, a chimera in my brain, troubles me in my prayer — John Donne
His utopia was a chimera.
3 : an individual, organ, or part consisting of tissues of diverse genetic constitution
A hybrid created through fusion of a sperm and an egg from different species is a chimera.
The recent scientific development should raise concern amongst the populace.
This news may conjure up ideas about Frankenstein-ish experiments. But chimeras aren’t always man-made—and there are a number of examples of human chimeras that already exist.
A chimera is essentially a single organism that’s made up of cells from two or more “individuals”—that is, it contains two sets of DNA, with the code to make two separate organisms.
One way that chimeras can happen naturally in humans is that a fetus can absorb its twin. This can occur with fraternal twins, if one embryo dies very early in pregnancy, and some of its cells are “absorbed” by the other twin. The remaining fetus will have two sets of cells, its own original set, plus the one from its twin. (Seeing Double: 8 Fascinating Facts About Twins)
These individuals often don’t know they are a chimera. For example, in 2002, news outlets reported the story of a woman named Karen Keegan, who needed a kidney transplant and underwent genetic testing along with her family, to see if a family member could donate one to her. But the tests suggested that genetically, Keegan could not be the mother of her sons. The mystery was solved when doctors discovered that Keegan was a chimera—she had a different set of DNA in her blood cells compared to the other tissues in her body.
A person can also be a chimera if they undergo a bone marrow transplant. During such transplants, which can be used for example to treat leukemia, a person will have their own bone marrow destroyed and replaced with bone marrow from another person. Bone marrow contains stem cells that develop into red blood cells. This means that a person with a bone marrow transplant will have blood cells, for the rest of their life, that are genetically identical to those of the donor, and are not genetically the same as the other cells in their own body.
In some cases, all of the blood cells in a person who received a bone marrow transplant will match the DNA of their donor. But in other cases, the recipient may have a mix of both their own blood cells and donor ones, according to a 2004 review paper in the journal Bone Marrow Transplantation. A blood transfusion will also temporarily give a person cells from someone else, but in a bone marrow transplant, the new blood cells are permanent, according to the Tech Museum of Innovation in San Jose, California.
More commonly, people may exhibit so-called microchimerism—when a small fraction of their cells are from someone else. This can happen when a woman becomes pregnant, and a small number of cells from the fetus migrate into her blood and travel to different organs.
A 2015 study suggested that this happens in almost all pregnant women, at least temporarily. The researchers tested tissue samples from the kidneys, livers, spleens, lungs, hearts, and brains of 26 women who tragically died while pregnant or within one month of giving birth. The study found that the women had fetal cells in all of these tissues. The researchers knew that the cells were from the fetus, and not from the mother, because the cells contained a Y chromosome (found only in males) and the women had all been carrying sons.
In some cases, fetal cells may stay in a woman’s body for years. In a 2012 study, researchers analyzed the brains of 59 women ages 32 to 101, after they had died. They found 63 percent of these women had traces of male DNA from fetal cells in their brains. The oldest woman to have fetal cells in her brain was 94 years old, suggesting that these cells can sometimes stay in the body for a lifetime.
- The 9 Most Interesting Transplants
- Inside Life Science: Once Upon a Stem Cell
- 11 Body Parts Grown in the Lab
How do you feel about Chimeras? Ethical hazard? Monstrosity? Abnormal? Wrong? Coolest fucking thing in the world? Nature’s strange way of adapting to inadequate or not quite desired scenarios? Let us know in the comments or join us in the discussion on our Twitter and Facebook.